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Tuesday, September 6, 2011
Sunday, July 13, 2008
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Side Effects Of Viagra
During clinical trials Viagra was tested on 3700 patients aging from nineteen to eighty seven and based on these results the various side effects of Viagra were decided upon. The adverse effects were generally so transitory and mild in nature that it appeared to be very little harmful to a human being.
In all the designs of the trials the adverse events that were reported by the patients taking VIAGRA were commonly similar. The occurrence of some adverse events amplified with dose. The nature of the adverse events in flexible-dose studies was similar to that for fixed-dose studies.
There were several reactions to be seen among 2% of the patients who were given Viagra whether at a fixed dosage or a flexible dosage and taking all the cases into account these reactions can be named accordingly. These were tested under controlled clinical trials. However, a causal relationship to Viagra is quite uncertain. Among many there is face edema and accidental injury. In the cardio vascular system Viagra causes such problems as angina pectoris, AV block and cardiomyopathy.
Viagra seems to affect the digestive system as well and in the following ways: vomiting, glossitis, colitis, dysphagia, gastritis, gastroenteritis, esophagitis, stomatitis, dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis. Anemia and leukopenia can also be two of the side effects of taking Viagra pills.
Viagra causes trouble in the nervous sytem as well. The adverse effects are listed as ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo, depression, insomnia, somnolence, abnormal dreams, reflexes decreased, hypesthesia. The respitory system is affected by the use of this drug and might cause asthma, cough increased.
Problems faced:
herpes simplex
urticaria
eye hemorrhage
cataract
dry eyes
Urogenital problems can also be faced by users like:
Cystitis
urinary incontinence
anorgasmia
Nocturia
abnormal ejaculation
genital edema
breast enlargement
urinary frequency
Some other adverse effects include:
bone pain
myasthenia
tenosynovitis
gout
Many of these incidents were registered to occur during or shortly after sexual activity, and a few were reported to occur shortly after the use of VIAGRA without sexual activity. Others were reported to have occurred hours to days after the use of VIAGRA and sexual activity. Serious cardiovascular, cerebrovascular, and vascular events, including myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, subarachnoid and intracerebral hemorrhages, and pulmonary hemorrhage have been reported post-marketing in temporal association with the use of VIAGRA. Most, but not all, of these patients had preexisting cardiovascular risk factors.
During clinical trials Viagra was tested on 3700 patients aging from nineteen to eighty seven and based on these results the various side effects of Viagra were decided upon. The adverse effects were generally so transitory and mild in nature that it appeared to be very little harmful to a human being.
In all the designs of the trials the adverse events that were reported by the patients taking VIAGRA were commonly similar. The occurrence of some adverse events amplified with dose. The nature of the adverse events in flexible-dose studies was similar to that for fixed-dose studies.
There were several reactions to be seen among 2% of the patients who were given Viagra whether at a fixed dosage or a flexible dosage and taking all the cases into account these reactions can be named accordingly. These were tested under controlled clinical trials. However, a causal relationship to Viagra is quite uncertain. Among many there is face edema and accidental injury. In the cardio vascular system Viagra causes such problems as angina pectoris, AV block and cardiomyopathy.
Viagra seems to affect the digestive system as well and in the following ways: vomiting, glossitis, colitis, dysphagia, gastritis, gastroenteritis, esophagitis, stomatitis, dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis. Anemia and leukopenia can also be two of the side effects of taking Viagra pills.
Viagra causes trouble in the nervous sytem as well. The adverse effects are listed as ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo, depression, insomnia, somnolence, abnormal dreams, reflexes decreased, hypesthesia. The respitory system is affected by the use of this drug and might cause asthma, cough increased.
Problems faced:
herpes simplex
urticaria
eye hemorrhage
cataract
dry eyes
Urogenital problems can also be faced by users like:
Cystitis
urinary incontinence
anorgasmia
Nocturia
abnormal ejaculation
genital edema
breast enlargement
urinary frequency
Some other adverse effects include:
bone pain
myasthenia
tenosynovitis
gout
Many of these incidents were registered to occur during or shortly after sexual activity, and a few were reported to occur shortly after the use of VIAGRA without sexual activity. Others were reported to have occurred hours to days after the use of VIAGRA and sexual activity. Serious cardiovascular, cerebrovascular, and vascular events, including myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, subarachnoid and intracerebral hemorrhages, and pulmonary hemorrhage have been reported post-marketing in temporal association with the use of VIAGRA. Most, but not all, of these patients had preexisting cardiovascular risk factors.
a
How Viagra Works
The erection depends on the amount of blood that flows into the penis. In order to increase the amount of blood that flows inside the penis there can be a few things that can be done. Like increasing the production of nitric oxide in the penis or increasing the amount of cyclic guanoosine monophospahte produced in the penis in response to the nitric oxide or just eliminating the PHOSPHO DIESTERASE ENZYME in the penis so that the cyclic guanoosine monophospahte builds up instead of getting decomposed by the PHOSPHO DIESTERASE ENZYME 5.
What Viagra does is use the third process and it eliminates the PHOSPHO DIESTERASE ENZYME 5. The PHOSPHO DIESTERASE ENZYME tends to decompose the cyclic guanoosine monophospahte. So cyclic guanoosine monophospahte builds up in the penis. It has a much larger effect on the artery walls. The greater the amount of cyclic guanoosine monophospahte the greater the blood flow. And with the increase of the blood flow increases the degree of the erection.
In the human body there are at least 11 different kinds of PHOSPHO DIESTERASE ENZYME that is produced and among these only one, phospho diesterase enzyme 5, is found primarily in the penis. Once this fact was discovered by the scientists, the creation of Viagra was relatively easier. All that Pfizer required to do was to find a chemical that would selectively block PHOSPHO DIESTERASE ENZYME 5 and that would do the trick. With the PHOSPHO DIESTERASE ENZYME 5 blocked, cyclic guanoosine monophospahte could build up in the penis and increase the blood flow there without affecting other parts of the body.
PHOSPHO DIESTERASE ENZYME 5 is an enzyme that is specially folded protein and it can speed up a chemical reaction. How Viagra works is a simple story. A man takes a Viagra pill. Then what happens is that the blood carrying the sildenafil citrate flows throughout the body. . Then the sildenafil citrate attaches to the PHOSPHO DIESTERASE ENZYME 5 enzyme in his penis and disables most of it. When the man becomes sexually aroused after that, the brain sends the normal message to the NANC cells in his penis, which produce nitric oxide as usual. The nitric oxide creates cyclic guanoosine monophospahte and this starts relaxing the arteries in his penis. Since the PHOSPHO DIESTERASE ENZYME 5 has been disabled, the cyclic guanoosine monophospahte in the penis does not break down. Instead, it builds up and lets the arteries in the penis fully dilate. The man’s penis inflates with blood, and he gets a full erection.
Another advantage of Viagra over an injection of phentolamine is that Viagra only causes an erection once the man has been sexually aroused. Phentolamine, by contrast, causes an immediate and uncontrolled erection.
Viagra only works once the man is sexually aroused. So it is best to take it one hour before having sex. Sometimes it has some adverse effects on particular people using the drugs and it affects the various systems of the body other than the penis.
The erection depends on the amount of blood that flows into the penis. In order to increase the amount of blood that flows inside the penis there can be a few things that can be done. Like increasing the production of nitric oxide in the penis or increasing the amount of cyclic guanoosine monophospahte produced in the penis in response to the nitric oxide or just eliminating the PHOSPHO DIESTERASE ENZYME in the penis so that the cyclic guanoosine monophospahte builds up instead of getting decomposed by the PHOSPHO DIESTERASE ENZYME 5.
What Viagra does is use the third process and it eliminates the PHOSPHO DIESTERASE ENZYME 5. The PHOSPHO DIESTERASE ENZYME tends to decompose the cyclic guanoosine monophospahte. So cyclic guanoosine monophospahte builds up in the penis. It has a much larger effect on the artery walls. The greater the amount of cyclic guanoosine monophospahte the greater the blood flow. And with the increase of the blood flow increases the degree of the erection.
In the human body there are at least 11 different kinds of PHOSPHO DIESTERASE ENZYME that is produced and among these only one, phospho diesterase enzyme 5, is found primarily in the penis. Once this fact was discovered by the scientists, the creation of Viagra was relatively easier. All that Pfizer required to do was to find a chemical that would selectively block PHOSPHO DIESTERASE ENZYME 5 and that would do the trick. With the PHOSPHO DIESTERASE ENZYME 5 blocked, cyclic guanoosine monophospahte could build up in the penis and increase the blood flow there without affecting other parts of the body.
PHOSPHO DIESTERASE ENZYME 5 is an enzyme that is specially folded protein and it can speed up a chemical reaction. How Viagra works is a simple story. A man takes a Viagra pill. Then what happens is that the blood carrying the sildenafil citrate flows throughout the body. . Then the sildenafil citrate attaches to the PHOSPHO DIESTERASE ENZYME 5 enzyme in his penis and disables most of it. When the man becomes sexually aroused after that, the brain sends the normal message to the NANC cells in his penis, which produce nitric oxide as usual. The nitric oxide creates cyclic guanoosine monophospahte and this starts relaxing the arteries in his penis. Since the PHOSPHO DIESTERASE ENZYME 5 has been disabled, the cyclic guanoosine monophospahte in the penis does not break down. Instead, it builds up and lets the arteries in the penis fully dilate. The man’s penis inflates with blood, and he gets a full erection.
Another advantage of Viagra over an injection of phentolamine is that Viagra only causes an erection once the man has been sexually aroused. Phentolamine, by contrast, causes an immediate and uncontrolled erection.
Viagra only works once the man is sexually aroused. So it is best to take it one hour before having sex. Sometimes it has some adverse effects on particular people using the drugs and it affects the various systems of the body other than the penis.
Viagra and Nitrates
One very important thing that you must remember about Viagra is that Viagra and Nitrates can’t be mixed! And when it is so done there can be really serious damage done to the human body and most importantly to the heart itself. So when a person goes for a treatment of his erectile dysfunction he should take special care about the drugs that he is given for it and check if it mixes with his other prescribed medication. Viagra is indeed a prescription drug and everybody should surely consult a physician before even considering taking up the pills for sexual health. If not taken with care and full knowledge Viagra can be potentially dangerous. Recently it came up in the news only because of mishaps that took place after this special care was not taken and some patients faced serious injuries and even death due to Viagra usage.
Doctors always state that Viagra is never, and strictly, never to be taken with nitrates and other drugs that include nitrate. The FDA's warning was issued in conjunction with Pfizer, the manufacturer of Viagra.
What nitrates do is cause the relaxation of the muscles that control the size of blood vessels. Now Viagra also do the same. After each of these chemicals effect the muscles and they begin to relax the vessels begin to get larger in diameter. This results in a considerable drop of the blood pressure. That is the reason why Viagra and nitrates are not to be taken together because the effects that both of the chemicals have on the blood pressure is much greater than what it is if either of the drugs are taken.
This radical drop in blood pressure is unfavorable to patients who have angina pectoris that is heart pain. In such a condition of the heart a higher pressure of blood is needed to flow to the heart and the heart then needs a much greater supply of blood. At this point of state if the blood pressure drops and the flow of blood to the pumping machine lowers then it can certainly lead to a heart attack.
But at the same time it is very true and even medically proved that sexual activity or exercise can precipitate a heart attack in patients with angina pectoris. Therefore it is very likely that it was never the combination of Viagra with nitrates that caused those deaths. But still it is suggested and warned that the two should not be mixed in any case to minimize all kinds of risks.
So a heart patient should consult his physician or cardiologist to make sure that the drugs that he takes for his heart condition does not contain nitrates. If he does then for his treatment of erectile dysfunction he can not take Viagra. His physician in that case will warn him against it and maybe prescribe something else to help him with his problems- something other than this particular drug.s
Doctors always state that Viagra is never, and strictly, never to be taken with nitrates and other drugs that include nitrate. The FDA's warning was issued in conjunction with Pfizer, the manufacturer of Viagra.
What nitrates do is cause the relaxation of the muscles that control the size of blood vessels. Now Viagra also do the same. After each of these chemicals effect the muscles and they begin to relax the vessels begin to get larger in diameter. This results in a considerable drop of the blood pressure. That is the reason why Viagra and nitrates are not to be taken together because the effects that both of the chemicals have on the blood pressure is much greater than what it is if either of the drugs are taken.
This radical drop in blood pressure is unfavorable to patients who have angina pectoris that is heart pain. In such a condition of the heart a higher pressure of blood is needed to flow to the heart and the heart then needs a much greater supply of blood. At this point of state if the blood pressure drops and the flow of blood to the pumping machine lowers then it can certainly lead to a heart attack.
But at the same time it is very true and even medically proved that sexual activity or exercise can precipitate a heart attack in patients with angina pectoris. Therefore it is very likely that it was never the combination of Viagra with nitrates that caused those deaths. But still it is suggested and warned that the two should not be mixed in any case to minimize all kinds of risks.
So a heart patient should consult his physician or cardiologist to make sure that the drugs that he takes for his heart condition does not contain nitrates. If he does then for his treatment of erectile dysfunction he can not take Viagra. His physician in that case will warn him against it and maybe prescribe something else to help him with his problems- something other than this particular drug.s
Thursday, July 10, 2008
Trial
CampuHigh Online High School
Founded in the year 1994 CompuHigh Online High School is the world’s first self proclaimed online school for higher education. CampuHigh Online High School has as many as 38 courses to offer across two major streams: Science and Humanities and also physical education to some extent. Students can either opt for full degree courses or just diplomas the only constraint being that they must be opting for courses of classes IX to XII. In fact CampuHigh Online High School is known for adults as old as 21 to have opted for diploma courses from this high school. Now this is something seriously to boast about.
The diploma CampuHigh Online High School is nationally accredited and operating Whitmore School. Besides there are two diploma courses in the offering which include:
General studies requiring 18 credits for graduation
College Preparation requiring 22 credits for graduation
CampuHigh Online High School boasts of accreditation by the North Central Association and the Southern Association of Colleges and Schools (although both are merely regional accreditors) besides the Commission on International and Transregional Accreditation.
A student can enroll at CompuHigh Online High School around the year and it only takes at most 24 hrs for the admission to be processed and finalized. One can join the school any time. Even better, credits from previous courses at other schools can be carried over however there are some restrictions stringed to it.
CampuHigh Online High School is probably one of the cheaper schools when it comes to tuition fees. The diploma program whether it is for General Studies or College Preparation costs as little as 985 USD annually and covers as many as eight credits. However there is an even more exhaustive program by the name of Diploma Plus which offers additional services which include educational counseling and even weekly progress reports for the parents which costs as much as 1485 USD annually. The hike in price for the Diploma Plus course does not really seem justified. However if you are really interested in it, the price is not that high either. Individual courses at CompuHigh Online High School cost only 275 USD which is really very nominal and the flat rate for adult education programs are fixed at 985 USD. These tuition fees cover all expenses of textbooks and the like saving you a hefty sum.
The online course interface has a rather informal yet conversational tone which uses simple text layouts and navigation techniques. However as a major drawback there are no graphics or photos or any attractive symbol to further make education at this school more interesting. The demos are free to be viewed by anybody anytime. However one good thing that I must mention about CompuHigh Online High School is that each course has its own teacher and students can directly approach the teachers through email and the response period is usually around 48 hours or less.
An interesting fact regarding CompuHigh Online High School is that the school holds a proper graduation ceremony at its West Virginia head quarters each June besides the online ones in January and August for students who are graduating anytime that year.
Founded in the year 1994 CompuHigh Online High School is the world’s first self proclaimed online school for higher education. CampuHigh Online High School has as many as 38 courses to offer across two major streams: Science and Humanities and also physical education to some extent. Students can either opt for full degree courses or just diplomas the only constraint being that they must be opting for courses of classes IX to XII. In fact CampuHigh Online High School is known for adults as old as 21 to have opted for diploma courses from this high school. Now this is something seriously to boast about.
The diploma CampuHigh Online High School is nationally accredited and operating Whitmore School. Besides there are two diploma courses in the offering which include:
General studies requiring 18 credits for graduation
College Preparation requiring 22 credits for graduation
CampuHigh Online High School boasts of accreditation by the North Central Association and the Southern Association of Colleges and Schools (although both are merely regional accreditors) besides the Commission on International and Transregional Accreditation.
A student can enroll at CompuHigh Online High School around the year and it only takes at most 24 hrs for the admission to be processed and finalized. One can join the school any time. Even better, credits from previous courses at other schools can be carried over however there are some restrictions stringed to it.
CampuHigh Online High School is probably one of the cheaper schools when it comes to tuition fees. The diploma program whether it is for General Studies or College Preparation costs as little as 985 USD annually and covers as many as eight credits. However there is an even more exhaustive program by the name of Diploma Plus which offers additional services which include educational counseling and even weekly progress reports for the parents which costs as much as 1485 USD annually. The hike in price for the Diploma Plus course does not really seem justified. However if you are really interested in it, the price is not that high either. Individual courses at CompuHigh Online High School cost only 275 USD which is really very nominal and the flat rate for adult education programs are fixed at 985 USD. These tuition fees cover all expenses of textbooks and the like saving you a hefty sum.
The online course interface has a rather informal yet conversational tone which uses simple text layouts and navigation techniques. However as a major drawback there are no graphics or photos or any attractive symbol to further make education at this school more interesting. The demos are free to be viewed by anybody anytime. However one good thing that I must mention about CompuHigh Online High School is that each course has its own teacher and students can directly approach the teachers through email and the response period is usually around 48 hours or less.
An interesting fact regarding CompuHigh Online High School is that the school holds a proper graduation ceremony at its West Virginia head quarters each June besides the online ones in January and August for students who are graduating anytime that year.
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